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Sulfates are the main circulating conjugates of ethinyl estradiol and glucuronides predominate in urine. The principal oxidative metabolite is 2-hydroxy ethinyl estradiol, fashioned because of the CYP3A4 isoform of cytochrome P450. Portion of the main-go metabolism of ethinyl estradiol is thought to come about in gastrointestinal mucosa. Ethinyl es